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Brain Perfusion Correlates of Apathy in Alzheimer's Disease
Dementia and Neurocognitive Disorders ; : 50-56, 2018.
Article Dans Anglais | WPRIM | ID: wpr-714836
ABSTRACT
BACKGROUND AND

PURPOSE:

Apathy is one of the most common neuropsychiatric symptoms in patients with Alzheimer's disease (AD). It may have adverse impacts on the progression of AD. However, its neurobiological underpinnings remain unclear. The objective of this study was to investigate differences in regional cerebral blood flow (rCBF) between AD patients with apathy and those without apathy.

METHODS:

Sixty-six apathetic AD patients and 66 AD patients without apathy completed Neuropsychiatric Inventory (NPI) and underwent technetium-99m hexamethylpropylene amine oxime single-photon emission computed tomography (SPECT) scans. Voxel-wise differences in rCBF between the 2 groups were examined. Association between rCBF and levels of apathy in the apathetic group was also assessed.

RESULTS:

AD patients with apathy showed lower rCBF in the bilateral orbitofrontal cortex, left putamen, left nucleus accumbens, left thalamus, and bilateral insula than those without (all p < 0.005). Mean perfusion across all significant clusters showed a negative linear correlation with NPI apathy score in AD patients with apathy (β = −0.25; p = 0.04).

CONCLUSIONS:

Hypoperfusion in the prefrontal, striatal, and insular areas may be neural correlates of apathy in AD patients.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Perfusion / Putamen / Débit sanguin régional / Thalamus / Encéphale / Tomoscintigraphie / Tomographie par émission monophotonique / Circulation cérébrovasculaire / Cortex préfrontal / Apathie Limites du sujet: Humains langue: Anglais Texte intégral: Dementia and Neurocognitive Disorders Année: 2018 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Perfusion / Putamen / Débit sanguin régional / Thalamus / Encéphale / Tomoscintigraphie / Tomographie par émission monophotonique / Circulation cérébrovasculaire / Cortex préfrontal / Apathie Limites du sujet: Humains langue: Anglais Texte intégral: Dementia and Neurocognitive Disorders Année: 2018 Type: Article