Visceral fat thickness and its associations with pubertal and metabolic parameters among girls with precocious puberty
Annals of Pediatric Endocrinology & Metabolism
; : 81-87, 2018.
Article
de En
| WPRIM
| ID: wpr-714974
Bibliothèque responsable:
WPRO
ABSTRACT
PURPOSE: This study aimed to investigate associations of central obesity with sexual maturation and metabolic parameters in Korean girls with precocious puberty. METHODS: This retrospective study evaluated data from 72 girls under 8 years of age with a chief complaint of early breast development. The patients were categorized as central precocious puberty (CPP) subjects or non-CPP subjects based on their gonadotropin-releasing hormone stimulation test results. Visceral fat thickness (VFT) was measured using ultrasonography and defined as the distance from the linea alba to the aorta. Patient anthropometric, metabolic, and hormonal parameters were also evaluated. RESULTS: Increased VFT was correlated with an earlier onset of thelarche among all study subjects (r=-0.307, P=0.034). Overweight CPP subjects showed higher insulin resistance than normal weight CPP subjects. Insulin resistance was not significantly different between overweight and normal weight non-CPP subjects. VFT was not significantly different between CPP and non-CPP subjects (2.22±0.79 cm vs. 2.74±1.47 cm, P=0.169). However, overweight and obese CPP subjects (body mass index percentile>85%) had lower VFT than non-CPP obese subjects. CONCLUSIONS: Central obesity, defined using ultrasonography-measured VFT, might be associated with early pubertal development in Korean girls. However, VFT was not higher in CPP than non-CPP patients and was not significantly correlated with insulin resistance. Further longitudinal studies with a larger cohort are needed.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Aorte
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Puberté précoce
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Maturation sexuelle
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Région mammaire
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Insulinorésistance
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Études rétrospectives
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Études de cohortes
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Études longitudinales
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Échographie
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Hormone de libération des gonadotrophines
Type d'étude:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Limites du sujet:
Female
/
Humans
langue:
En
Texte intégral:
Annals of Pediatric Endocrinology & Metabolism
Année:
2018
Type:
Article