Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 120-127, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-715070
ABSTRACT
OBJECTIVES:
The aim of this study was to reveal how collagenases (matrix metalloproteinase [MMP]-1, 8, 13) and tissue inhibitor of metalloproteinase 1 (TIMP-1) are expressed in immunohistochemistry of retrodiscal tissue in temporomandibular joint disorder patients. MATERIALS ANDMETHODS:
This study was conducted on 39 patients who underwent discoplasty or discectomy. Immunohistochemical staining was undertaken and expression levels of MMP-1, 8, 13, and TIMP-1 were evaluated. The status of internal derangement of disc, osteoarthritis, and joint effusion were analyzed using magnetic resonance imaging (MRI). Disc status observed during operation was also categorized.RESULTS:
The more severe disc derangement was observed on MRI, the more increased expression of MMPs and TIMP-1 appeared. Regarding MMP-13 expression, 86.7% of late-stage disc displacement patients showed grade II or III. Expression level of MMPs or TIMP was not statistically significant associated with joint effusion level. In perforation and/or adhesion groups, all patients showed grade II or III expression of MMP-13. Once perforation occurred, MMP-13 showed increased expression with statistical significance.CONCLUSION:
MMP-1 and MMP-13 expression seem to be related to progression of osteoarthritis whereas MMP-8 does not seem to have a specific role with regard to temporomandibular joint disorders. TIMP-1 is considered to be partly related to internal derangement rather than osteoarthritis, but it is not significant.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Arthrose
/
Articulation temporomandibulaire
/
Immunohistochimie
/
Imagerie par résonance magnétique
/
Troubles de l'articulation temporomandibulaire
/
Collagenases
/
Discectomie
/
Inhibiteur tissulaire de métalloprotéinase-1
/
Matrix metalloproteinases
/
Articulations
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Année:
2018
Type:
Article
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