Lack of Association between Helicobacter pylori Infection and Various Markers of Systemic Inflammation in Asymptomatic Adults / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 21-27, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-715643
ABSTRACT
BACKGROUND/AIMS:
Helicobacter pylori (H. pylori) infection has been known to cause various extra-gastric diseases, which may be mediated by an increase in systemic inflammation. Thus, we examined the association between H. pylori infection and various markers of systemic inflammation in a large sample of asymptomatic adults.METHODS:
Cross-sectional data were obtained from 17,028 adults who completed routine health check-ups. H. pylori infection status was determined using a serum immunoglobulin G test, and systemic inflammation was assessed using the C-reactive protein (CRP) levels, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR).RESULTS:
Multiple linear regression model-adjusted for potential confounders-revealed that H. pylori infection was not associated with CRP levels (coefficient −0.012, 95% confidence interval [CI] −0.037, 0.012, p=0.319), NLR (coefficient 0.055, 95% CI −0.027, 0.138, p=0.192), or PLR (coefficient 1.798, 95% CI −1.979, 5.574, p=0.351). In a multivariable logistic regression model, H. pylori infection was not associated with the risk of CRP levels being elevated to ≥0.1 mg/dL (odds ratio 0.96, 95% CI 0.81, 1.08) or ≥0.3 mg/dL (odds ratio 1.02, 95% CI 0.84, 1.19). In the multivariable model, CRP levels elevated to ≥0.1 mg/dL were significantly associated with body mass index, current smoking status, hypertension, and diabetes mellitus. Regular exercise and high-density lipoprotein cholesterol were factors that minimized the elevation of CRP levels.CONCLUSIONS:
Chronic infection with H. pylori was not associated with various inflammatory markers. Further investigation is needed to clarify the interaction between H. pylori infection, systemic inflammation, and extra-gastric disease.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Fumée
/
Protéine C-réactive
/
Immunoglobuline G
/
Fumer
/
Indice de masse corporelle
/
Modèles linéaires
/
Modèles logistiques
/
Cholestérol
/
Helicobacter pylori
/
Helicobacter
Type d'étude:
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Humains
langue:
Anglais
Texte intégral:
The Korean Journal of Gastroenterology
Année:
2018
Type:
Article
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