The association between new generation oral contraceptive pill and the development of inflammatory bowel diseases
Intestinal Research
;
: 409-415, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-715878
ABSTRACT
BACKGROUND/AIMS:
To examine the association between use of oral contraceptive pills (OCPs) and the risk of developing inflammatory bowel diseases (IBD), in a modern cohort.METHODS:
A prospective nested case-control study across sites in the Asia-Pacific region was conducted; involving female IBD cases and asymptomatic controls. Subjects completed a questionnaire addressing questions related to OCP use. Primary outcome was the risk of development of IBD of those exposed to OCP versus non-exposure. Secondary outcomes were development of Crohn's disease (CD) versus ulcerative colitis (UC), and whether age of first use of OCP use may be associated with risk of IBD.RESULTS:
Three hundred and forty-eight female IBD cases (41% CD, median age 43 years) and 590 female age-matched controls were recruited. No significant association was found between OCP use and the risk of IBD (odds ratio [OR], 1.65; 95% confidence interval, 0.77–3.13; P=0.22), CD (OR, 1.55) or UC (OR, 1.01). The lack of association persisted when results were adjusted for age and smoking. IBD cases commenced OCP use at a younger age than controls (18 years vs. 20 years, P=0.049).CONCLUSIONS:
In this large cohort of subjects from the Asia-Pacific region, we found a modest but not significantly increased risk of developing IBD amongst OCP users.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Fumée
/
Maladies inflammatoires intestinales
/
Fumer
/
Rectocolite hémorragique
/
Maladie de Crohn
/
Études cas-témoins
/
Études prospectives
/
Études de cohortes
/
Contraceptifs oraux
Type d'étude:
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Intestinal Research
Année:
2018
Type:
Article
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