Damage-Associated Molecular Patterns in Inflammatory Diseases
Immune Network
;
: e27-2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-716244
ABSTRACT
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although DAMPs contribute to the host's defense, they promote pathological inflammatory responses. Recent studies have suggested that various DAMPs, such as high-mobility group box 1 (HMGB1), S100 proteins, and heat shock proteins (HSPs), are increased and considered to have a pathogenic role in inflammatory diseases. Here, we review current research on the role of DAMPs in inflammatory diseases, including rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, atherosclerosis, Alzheimer's disease, Parkinson's disease, and cancer. We also discuss the possibility of DAMPs as biomarkers and therapeutic targets for these diseases.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Arthrose
/
Maladie de Parkinson
/
Polyarthrite rhumatoïde
/
Marqueurs biologiques
/
Protéines S100
/
Athérosclérose
/
Récepteurs de reconnaissance de motifs moléculaires
/
Maladie d'Alzheimer
/
Protéines du choc thermique
/
Système immunitaire
langue:
Anglais
Texte intégral:
Immune Network
Année:
2018
Type:
Article
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