Associations between Body Mass Index and Chronic Kidney Disease in Type 2 Diabetes Mellitus Patients: Findings from the Northeast of Thailand
Diabetes & Metabolism Journal
; : 330-337, 2018.
Article
de En
| WPRIM
| ID: wpr-716314
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND: Chronic kidney disease (CKD) has emerged as a public health burden globally. Obesity and long-term hyperglycaemia can initiate the renal vascular complications in patients with type 2 diabetes mellitus (T2DM). This study aimed to investigate the association of body mass index (BMI) with the CKD in patients with T2DM. METHODS: This study has used retrospective medical records, biochemical reports, and anthropometric measurements of 3,580 T2DM patients which were collected between January to December 2015 from a district hospital in Thailand. CKD was defined according to the measurement of estimated glomerular filtration rate ( < 60 mL/min/1.73 m2). Multiple logistic regression analysis was used to explore the association between BMI and CKD in patients with T2DM. RESULTS: The mean age of the participants was 60.86±9.67 years, 53.68% had poor glycaemic control, and 45.21% were overweight. About one-in-four (23.26%) T2DM patients had CKD. The mean BMI of non-CKD group was slightly higher (25.30 kg/m2 vs. 24.30 kg/m2) when compared with CKD patients. Multivariable analysis showed that older age, female sex, hypertension, and microalbuminuria were associated with the presence of CKD. No association was observed between CKD and poorly controlled glycosylated hemoglobin or hypercholesterolemia. Adjusted analysis further showed overweight and obesity were negatively associated with CKD (adjusted odds ratio [AOR], 0.73; 95% confidence interval [CI], 0.58 to 0.93) and (AOR, 0.53; 95% CI, 0.35 to 0.81), respectively. CONCLUSION: The negative association of BMI with CKD could reflect the reverse causality. Lower BMI might not lead a diabetic patient to develop CKD, but there are possibilities that CKD leads the patient to experience reduced BMI.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Thaïlande
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Hémoglobine glyquée
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Indice de masse corporelle
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Modèles logistiques
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Odds ratio
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Dossiers médicaux
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Santé publique
/
Études rétrospectives
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Diabète de type 2
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Insuffisance rénale chronique
Type d'étude:
Diagnostic_studies
/
Etiology_studies
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Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites du sujet:
Female
/
Humans
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Diabetes & Metabolism Journal
Année:
2018
Type:
Article