Functional Characterization of the Major Outer Membrane Protein ( MspTL ) of Treponema lecithinolyticum
Journal of Bacteriology and Virology
;
: 47-54, 2002.
Article
Dans Coréen
| WPRIM
| ID: wpr-71647
ABSTRACT
Treponema lecithinolyticum is known to be associated with rapidly progressive periodontitis. The full-length gene encoding the major surface protein MspTL of this organism was cloned and expressed by using the expression vector pQE30. Recombinant Msp TL (rMsp TL) protein was purified and functionally characterized. Msp TL was one of several T. lecithinolyticum surface proteins that bound to cultured human gingival fibroblasts (HGFs). As well, it strongly induced IL-6 production by HGFs. These observations suggest that MspTL contributes to pathogenesis of periodontitis by adhesion to host cells and by induction of the proinflammatory cytokine IL-6.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Parodontite
/
Treponema
/
Interleukine-6
/
Clones cellulaires
/
Fibroblastes
/
Protéines membranaires
/
Membranes
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Journal of Bacteriology and Virology
Année:
2002
Type:
Article
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