The Fas Signaling Pathway Is a Common Genetic Risk Factor for Severe Cutaneous Drug Adverse Reactions Across Diverse Drugs
Allergy, Asthma & Immunology Research
;
: 555-561, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-716676
ABSTRACT
PURPOSE:
Human leukocyte antigen (HLA) has been recognized as the most important genetic risk factor for severe cutaneous adverse drug reactions (SCARs) caused by certain drugs. However, cumulated observations suggest the presence of genetic risk factors for SCARs other than drug-specific HLA. We aimed to identify a common genetic risk factor of SCARs across multiple drugs.METHODS:
We performed 2 independent genome-wide association studies (GWASs). A total of 68 and 38 subjects with a diagnosis of SCAR were enrolled in each GWAS. Their allele frequencies were compared to those of healthy subjects in Korea.RESULTS:
No single nucleotide polymorphism (SNP) with genome-wide significance was found in either GWAS. We next selected and annotated the 200 top-ranked SNPs from each GWAS. These 2 sets of annotated genes were then entered into the web interface of ConsensusPathDB for a pathway-level analysis. The Fas signaling pathway was significantly over-represented in each gene set from the 2 GWASs.CONCLUSIONS:
Our observations suggest that the Fas signaling pathway may be a common genetic risk factor for SCARs across multiple drugs.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Facteurs de risque
/
Cicatrice
/
Syndrome de Stevens-Johnson
/
Polymorphisme de nucléotide simple
/
Diagnostic
/
Effets secondaires indésirables des médicaments
/
Étude d'association pangénomique
/
Volontaires sains
/
Fréquence d'allèle
/
Corée
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Humains
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Allergy, Asthma & Immunology Research
Année:
2018
Type:
Article
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