What should be done for men with sperm DNA fragmentation? / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
; : 101-109, 2018.
Article
Dans En
| WPRIM
| ID: wpr-716905
Responsable en Bibliothèque :
WPRO
ABSTRACT
In an age when a small quantity of sperm can lead to pregnancy through in vitro fertilization or intracytoplasmic sperm injection, selecting healthy sperm is important. Sperm DNA fragmentation (SDF) is known to be higher in infertile men. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) and the alkaline comet test are SDF tests that directly measure DNA damage and have shown closer correlations with assisted reproduction results than indirect tools such as the sperm chromatin structure assay or the sperm chromatic dispersion test. It is difficult; however, to endorse a single test as the best test overall; instead, it is best to select a testing method based on each patient's clinical condition and goals. In a couple struggling with infertility, if the male partner has a high level of SDF, he should aim to decrease SDF through lifestyle modifications, antioxidant treatment, and ensuring an appropriate duration of abstinence, and physicians need to treat the underlying diseases of such patients. If sperm DNA damage continues despite the patient's and physician's efforts, other methods, such as micromanipulation-based sperm selection or testicular sperm extraction, should be used to select healthy sperm with nuclear DNA integrity.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Reproduction
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Spermatozoïdes
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Altération de l'ADN
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ADN
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Chromatine
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Fécondation in vitro
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Injections intracytoplasmiques de spermatozoïdes
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Techniques de reproduction assistée
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Désoxyuridine
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Fragmentation de l'ADN
Limites du sujet:
Humans
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Male
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Pregnancy
langue:
En
Texte intégral:
Clinical and Experimental Reproductive Medicine
Année:
2018
Type:
Article