Abnormal Human Sperm Parameters Contribute to Sperm DNA Fragmentation in Men with Varicocele
The World Journal of Men's Health
;
: 239-247, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-716912
ABSTRACT
PURPOSE:
This study was performed to evaluate and compare threshold sperm parameters and sperm DNA fragmentation index (DFI), and further analyzed whether sperm DFI could be predicted from sperm parameters in men with varicocele. MATERIALS ANDMETHODS:
A total of 157 semen samples underwent both semen analysis and sperm DNA fragmentation (SDF) testing in men with varicocele. Sperm parameters were assessed using the World Health Organization guidelines. SDF testing was performed using the Halosperm kit. Sperm parameters and sperm DFI results were compared.RESULTS:
The overall sperm parameter results and sperm DFI showed normal values; however, the morphology value was at the lower limit of normal. High sperm DFI was associated with significantly lower motility and viability (p < 0.001, respectively). Sperm motility and morphology were significantly higher in the higher sperm count group compared to the lower sperm count group (p < 0.05), while sperm DFI was higher in the lower sperm count group (p < 0.05). Sperm count and viability and sperm DFI were significantly associated with the quality of sperm motility (p < 0.001). Sperm motility and sperm DFI were significantly different (p < 0.001) between normal and abnormal sperm viability groups. Between normal and abnormal sperm morphology groups, sperm count, motility, and sperm DFI showed significant differences (p < 0.001).CONCLUSIONS:
In this study, a correlation between SDF and sperm parameters was confirmed in men with varicocele. SDF may be contributing factors to sperm motility, viability, and morphology. Abnormal sperm count, motility, and viability showed high sperm DFI. Therefore, lower sperm parameters were indicative of increasing SDF in men with varicocele.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Valeurs de référence
/
Sperme
/
Numération des spermatozoïdes
/
Mobilité des spermatozoïdes
/
Spermatogenèse
/
Spermatozoïdes
/
Varicocèle
/
Organisation mondiale de la santé
/
ADN
/
Fragmentation de l'ADN
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
The World Journal of Men's Health
Année:
2018
Type:
Article
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