A Case of Wernicke's Encephalopathy Following Fluorouracil-based Chemotherapy
Journal of Korean Medical Science
;
: 747-750, 2009.
Article
Dans Anglais
| WPRIM
| ID: wpr-71709
ABSTRACT
The pyrimidine antimetabolite 5-fluorouracil (5-FU) is a chemotherapeutic agent used widely for various tumors. Common side effects of 5-FU are related to its effects on the bone marrow and gastrointestinal epithelium. Neurotoxicity caused by 5-FU is uncommon, although acute and delayed forms have been reported. Wernicke's encephalopathy is an acute, neuropsychiatric syndrome resulting from thiamine deficiency, and has significant morbidity and mortality. Central nervous system neurotoxicity such as Wernicke's encephalopathy following chemotherapy with 5-FU has been reported rarely, although it has been suggested that 5-FU can produce adverse neurological effects by causing thiamine deficiency. We report a patient with Wernicke's encephalopathy, reversible with thiamine therapy, associated with 5-FU-based chemotherapy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Thiamine
/
Carence en thiamine
/
Encéphalopathie de Gayet-Wernicke
/
Imagerie par résonance magnétique
/
Tumeurs du rhinopharynx
/
Maladie aigüe
/
Fluorouracil
/
Antimétabolites antinéoplasiques
Limites du sujet:
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Journal of Korean Medical Science
Année:
2009
Type:
Article
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