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Prospective Single Arm Study on the Effect of Ilaprazole in Patients with Heartburn but No Reflux Esophagitis
Yonsei Medical Journal ; : 951-959, 2018.
Article Dans Anglais | WPRIM | ID: wpr-717934
ABSTRACT

PURPOSE:

Patients with gastroesophageal reflux disease without esophagitis show varying responses to proton pump inhibitors (PPIs). The aim of this study was to objectively evaluate the effect of a new PPI, ilaprazole, on patients with heartburn but without reflux esophagitis. MATERIALS AND

METHODS:

This prospective study was performed on 20 patients with heartburn but without reflux esophagitis. All patients underwent upper endoscopy and 24-hr combined multichannel intraluminal impedance and pH esophageal monitoring (MII-pH). They were then treated with ilaprazole (20 mg) once daily for 4 weeks. The GerdQ questionnaire, histologic findings, and inflammatory biomarkers were used for assessment before and after ilaprazole.

RESULTS:

Among the 20 patients, 13 (65%) showed GerdQ score ≥8. Based on MII-pH results, patients were classified as true nonerosive reflux disease (n=2), hypersensitive esophagus (n=10), and functional heartburn (n=8). After treatment, patients showed a statistically significant improvement in GerdQ score (p < 0.001). Among histopathologic findings, basal cell hyperplasia, papillary elongation, and infiltration of intraepithelial T lymphocytes improved significantly (p=0.008, p=0.021, and p=0.008; respectively). Expression of TNF-α, IL-8, TRPV1, and MCP-1 decreased marginally after treatment (p=0.049, p=0.046, p=0.045, and p=0.042; respectively).

CONCLUSION:

Daily ilaprazole (20 mg) is efficacious in improving symptom scores, histopathologic findings, and inflammatory biomarkers in patients with heartburn but no reflux esophagitis.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Bras / Lymphocytes T / Marqueurs biologiques / Oesophagite peptique / Reflux gastro-oesophagien / Études prospectives / Interleukine-8 / Impédance électrique / Endoscopie / Oesophagite Type d'étude: Étude observationnelle Limites du sujet: Humains langue: Anglais Texte intégral: Yonsei Medical Journal Année: 2018 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Bras / Lymphocytes T / Marqueurs biologiques / Oesophagite peptique / Reflux gastro-oesophagien / Études prospectives / Interleukine-8 / Impédance électrique / Endoscopie / Oesophagite Type d'étude: Étude observationnelle Limites du sujet: Humains langue: Anglais Texte intégral: Yonsei Medical Journal Année: 2018 Type: Article