White-Matter Hyperintensities and Lacunar Infarcts Are Associated with an Increased Risk of Alzheimer's Disease in the Elderly in China
Journal of Clinical Neurology
; : 46-53, 2019.
Article
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| WPRIM
| ID: wpr-719300
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ABSTRACT
BACKGROUND AND PURPOSE: This study investigated the contribution of white-matter hyperintensities (WMH) and lacunar infarcts (LI) to the risk of Alzheimer's disease (AD) in an elderly cohort in China. METHODS: Older adults who were initially cognitively normal were examined with MRI at baseline, and followed for 5 years. WMH were classified as mild, moderate, or severe, and LI were classified into a few LI (1 to 3) or many LI (≥4). Cognitive function was assessed using the Mini Mental State Examination and the Activities of Daily Living scale. RESULTS: Among the 2,626 subjects, 357 developed AD by the end of the 5-year follow-up period. After adjusting for age and other potential confounders, having only WMH, having only LI, and having both WMH and LI were associated with an increased risk of developing AD compared with having neither WMH nor LI. Moderate and severe WMH were associated with an increased risk of developing AD compared with no WMH. Furthermore, patients with many LI had an increased risk of developing AD compared with no LI. CONCLUSIONS: Having moderate or severe WMH and many LI were associated with an increased risk of developing AD, with this being particularly striking when both WMH and LI were present.
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Indice:
WPRIM
Sujet Principal:
Grèves
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Activités de la vie quotidienne
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Imagerie par résonance magnétique
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Chine
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Études de cohortes
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Études de suivi
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Cognition
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Maladie d'Alzheimer
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Accident vasculaire cérébral lacunaire
Type d'étude:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limites du sujet:
Adult
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Aged
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Humans
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Journal of Clinical Neurology
Année:
2019
Type:
Article