Dosage-Related Prebiotic Effects of Inulin in Formula-Fed Infants / 대한소아소화기영양학회지
Pediatric Gastroenterology, Hepatology & Nutrition
;
: 63-71, 2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-719606
ABSTRACT
PURPOSE:
The aim of this study was to identify the minimally meaningful dosage of inulin leading to a prebiotic effect in Indonesian infants.METHODS:
In a randomized controlled double-blinded, parallel, 3-arm intervention study, 164 healthy formula-fed infants aged 3 to 5 months first obtained formula-A (without inulin) during a 4-week adaptation period. Subsequently, 142 subjects were subjected to a 4-week feeding period by administering either formula-A (no inulin), formula-B (0.2 g/100 mL inulin) or formula-C (0.4 g/100 mL inulin). The primary outcome parameter was %-bifidobacteria in faecal samples determined using quantitative polymerase chain reaction analyses. Secondary outcome parameters were faecal %-lactobacilli, pH and stool frequency, and consistency. Growth and tolerance/adverse effects were recorded as safety parameters.RESULTS:
Typical %-bifidobacteria and %-lactobacilli at the end of the adaptation period in the study population were 14% and 2%, respectively. For faecal pH, significant differences between formula groups A vs. C and A vs. B were found at the end of the intervention period. Testing for differences in faecal %-bifidobacteria and %-lactobacilli between groups was hampered by non-normal data set distributions; no statistically significant differences were obtained. Comparisons within groups revealed that only in formula group C, all the three relevant parameters exhibited a significant effect with an increase in faecal %-bifidobacteria and %-lactobacilli and a decrease in pH.CONCLUSION:
A consistent prebiotic effect along with a decrease in pH and increase in %-bifidobacteria and %-lactobacilli was found only in the group administered 0.4 g inulin/100 mL.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Réaction de polymérisation en chaîne
/
Préparation pour nourrissons
/
Prébiotiques
/
Ensemble de données
/
Microbiome gastro-intestinal
/
Concentration en ions d'hydrogène
/
Inuline
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Humains
/
Bébé
langue:
Anglais
Texte intégral:
Pediatric Gastroenterology, Hepatology & Nutrition
Année:
2019
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS