Galectin-8 Expression in Laryngeal Squamous Cell Carcinoma
Clinical and Experimental Otorhinolaryngology
; : 13-19, 2009.
Article
Dans En
| WPRIM
| ID: wpr-72009
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVES: Despite the ongoing development of treatment protocols for laryngeal squamous cell carcinoma (LSCC), the patients suffering with this malady have shown only a modestly improved outcome. This poor outcome has been attributed to the lack of therapy that's individualized to the tumor's biological properties. Various studies have showed that galectin-8 is widely expressed in tumor tissues as well as in normal tissues, and the level of the galectin-8 expression may correlate with the malignancy of human squamous cell carcinoma. The purpose of this study is to evaluate the expression of galectin-8 and to investigate its correlations with the primary stage, the nodal involvement, the clinical stage and the histologic grade of squamous cell carcinoma of the larynx. METHODS: The paraffin-embedded tissue specimens from 77 patients who were diagnosed as LSCC between 1993 and 2007 were immunohistochemically stained for galectin-8. RESULTS: Immunohistochemical analysis showed that a strong positive expression of galectin-8 was correlated with the T-stages, the nodal stages and the clinical stages. However, the histopathologic grades were not correlated with the galectin-8 expression in LSCC. CONCLUSION: The expression of galectin-8 protein can be used as a prognostic factor for patients with LSCC.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Stress psychologique
/
Immunohistochimie
/
Carcinome épidermoïde
/
Protocoles cliniques
/
Larynx
Type d'étude:
Guideline
/
Prognostic_studies
Limites du sujet:
Humans
langue:
En
Texte intégral:
Clinical and Experimental Otorhinolaryngology
Année:
2009
Type:
Article