Occurence of 17p Deletion with Blast Transformation in Idiopathic Myelofibrosis Treated with Hydroxyurea / 대한혈액학회지
Korean Journal of Hematology
;
: 46-50, 2004.
Article
Dans Coréen
| WPRIM
| ID: wpr-720090
ABSTRACT
The recently described '17p deletion syndrome' is a clonal hematologic disease which has characteristic dysgranulopoietic features, such as pseudo-Pelger-Huet hypogranulation and small vacuoles in neutrophils and is strongly associated with p53 mutation. The cases with 17p deletion are seen in 3~4% of myelodysplastic syndrome and acute myelogenous leukemia and about 30% of them are therapy-related. Hydroxyurea, which is considered to have relatively low leukemogenic potential, has therefore been widely used in chronic myeloproliferative disease. But the recent study has found that hydroxyurea administration is a considerable risk for later leukemic transformation and is closely associated with development of 17p deletion. We report one case of idiopathic myelofibrosis which developed 17p deletion with blast increment after hydroxyurea therapy for 3 years.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Vacuoles
/
Syndromes myélodysplasiques
/
Activation des lymphocytes
/
Leucémie aigüe myéloïde
/
Myélofibrose primitive
/
Hémopathies
/
Hydroxy-urée
/
Granulocytes neutrophiles
langue:
Coréen
Texte intégral:
Korean Journal of Hematology
Année:
2004
Type:
Article
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