Tumor Lysis Syndrome in Lymphoblastic Crisis of CML
Korean Journal of Hematology
;
: 119-123, 2006.
Article
Dans Anglais
| WPRIM
| ID: wpr-720232
ABSTRACT
Tumor lysis syndrome (TLS) defines the metabolic derangements that occur with tumor breakdown following the initiation of cytotoxic therapy. TLS results from the rapid destruction of malignant cells and the abrupt release of intracellular materials and their metabolites into the extracellular space. The syndrome causes hyperuricemia, hyperkalemia, hyperphosphatemia, secondary hypocalcemia and uremia. It can result in acute renal failure and be fatal. Early recognition of patient at risk and preventive measures are important. There is a high incidence of TLS in tumors with high proliferative rates and large burden such as acute lymphoblastic leukemia and Burkitt's lymphoma. It less commonly occurs in solid tumors such as testicular cancer, breast cancer and small cell lung cancer. There are only a few reports on TLS complicated in CML in blast crisis. So we report a 45-yr-old woman presenting with TLS associated with CML in lymphoblastic crisis after the initiation of cytotoxic chemotherapy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs du testicule
/
Urémie
/
Tumeurs du sein
/
Syndrome de lyse tumorale
/
Crise blastique
/
Incidence
/
Lymphome de Burkitt
/
Hyperuricémie
/
Traitement médicamenteux
/
Espace extracellulaire
Type d'étude:
Etude d'incidence
/
Étude pronostique
Limites du sujet:
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Korean Journal of Hematology
Année:
2006
Type:
Article
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