Bortezomib Therapy Followed by Autologous Stem Cell Transplantation in POEMS Syndrome
Korean Journal of Hematology
;
: 145-149, 2008.
Article
Dans Anglais
| WPRIM
| ID: wpr-720518
ABSTRACT
BACKGROUND:
The acronym POEMS refers to polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes. Increased levels of cytokines, including vascular endothelial growth factor (VEGF), appear to play a pathogenic role. POEMS syndrome is progressive and eventually leads to death from neurological problem without therapy.METHODS:
We treated 3 patients affected by POEMS syndrome with front-line bortezomib treatment and the high-dose melphalan with autologous stem cell transplantation (ASCT).RESULTS:
Bortezomib reduced circulating levels of VEGF in sera. After a median follow-up of 18 months (range, 16~20), all patients are alive with progressive improvement in neurological disease, skin changes, performance status and have no evidence of clonal plasmacytosis or organomegaly.CONCLUSION:
ASCT following bortezomib treatment may be a potential treatment option for patients with POEMS syndrome.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polyneuropathies
/
Pyrazines
/
Peau
/
Maladies de la peau
/
Cellules souches
/
Acides boroniques
/
Études de suivi
/
Cytokines
/
Syndrome POEMS
/
Neuropathies périphériques
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Korean Journal of Hematology
Année:
2008
Type:
Article
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