Meta-analysis for genome-wide association studies using case-control design: application and practice / 한국역학회지
Epidemiology and Health
;
: e2016058-2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-721142
ABSTRACT
This review aimed to arrange the process of a systematic review of genome-wide association studies in order to practice and apply a genome-wide meta-analysis (GWMA). The process has a series of five steps:
searching and selection, extraction of related information, evaluation of validity, meta-analysis by type of genetic model, and evaluation of heterogeneity. In contrast to intervention meta-analyses, GWMA has to evaluate the Hardy–Weinberg equilibrium (HWE) in the third step and conduct meta-analyses by five potential genetic models, including dominant, recessive, homozygote contrast, heterozygote contrast, and allelic contrast in the fourth step. The ‘genhwcci’ and ‘metan’ commands of STATA software evaluate the HWE and calculate a summary effect size, respectively. A meta-regression using the ‘metareg’ command of STATA should be conducted to evaluate related factors of heterogeneities.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Caractéristiques de la population
/
Études cas-témoins
/
Étude d'association pangénomique
/
Hétérozygote
/
Homozygote
/
Modèles génétiques
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
/
Revues systématiques évaluées
langue:
Anglais
Texte intégral:
Epidemiology and Health
Année:
2016
Type:
Article
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