Intestinal obstruction: predictor of poor prognosis in colorectal carcinoma? / 한국역학회지
Epidemiology and Health
;
: e2015017-2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-721190
ABSTRACT
OBJECTIVES:
The goal of this study was to assess the relationship between intestinal obstruction and the prognosis of colorectal carcinoma.METHODS:
Data pertaining to 4,501 colorectal carcinoma patients were extracted from the national colorectal registry and analysed. Survival analysis was performed using the Kaplan-Meier method. The log-rank test was used to compare the survival rate between patients with intestinal obstruction and those without intestinal obstruction. The p-values<0.05 were considered to indicate statistical significance. Simple Cox proportional hazards regression analysis was used to estimate the crude hazard ratio of mortality from colorectal cancer.RESULTS:
Intestinal obstruction was reported in more than 13% of patients. The 3-year survival rate after treatment was 48.3% (95% confidence interval [CI], 43.9 to 52.8) for patients with intestinal obstruction (n=593) and 54.9% (95% CI, 53.1 to 56.6) for patients without intestinal obstruction (n=3,908). The 5-year survival rate for patients with intestinal obstruction was 37.3% (95% CI, 31.9 to 42.8), which was lower than that of patients without intestinal obstruction (45.6%; 95% CI, 43.5 to 47.7). After adjusting the hazard ratio for other prognostic variables, intestinal obstruction had a statistically significant negative correlation with the survival rate of colorectal cancer patients, with an adjusted hazard ratio of 1.22 (p=0.008).CONCLUSIONS:
The presence of intestinal obstruction is associated with a lower survival rate among colorectal cancer patients.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Tumeurs colorectales
/
Taux de survie
/
Mortalité
/
Occlusion intestinale
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Epidemiology and Health
Année:
2015
Type:
Article
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