Evaluation of a New Diagnostic Test for Invasive Fungal Infections Using Prophenoloxydase System to Measure (1->3)-beta-D-glucan Concentration / 감염과화학요법
Infection and Chemotherapy
;
: 146-153, 2006.
Article
Dans Coréen
| WPRIM
| ID: wpr-721476
ABSTRACT
BACKGROUND:
Prognosis of invasive fungal infection is supposed to be better when diagnosed earlier. (1->3)-beta-D-glucan (BDG) test is considered useful in early diagnosis of invasive fungal infections among high-risk patients. A new diagnostic test using prophenoloxydase system to measure BDG level is developed. A study was performed to evaluate clinical usefulness of this new diagnostic test. MATERIALS ANDMETHODS:
15 patients of confirmed invasive fungal infections and 38 healthy normal volunteers were enrolled. Plasma or serum BDG concentrations were measured using prophenoloxydase system. Assays for intra-run variability and inter-run variability were performed. A cut-off value was determined and sensitivity and specificity of the test were evaluated.RESULTS:
A cut-off value of 94.90 pg/mL was determined. Sensitivity and specificity of the test were 86.7% and 52.6%, respectively. Statistical analyses of inter-run variability and intra-run variability revealed the test is reliable (P< or =0.001).CONCLUSION:
BDG test using prophenoloxydase system is a sensitive and reliable test in non-invasive detection of invasive fungal infection.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plasma sanguin
/
Pronostic
/
Sensibilité et spécificité
/
Diagnostic précoce
/
Tests diagnostiques courants
/
Volontaires sains
Type d'étude:
Etude diagnostique
/
Étude pronostique
/
Étude de dépistage
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Infection and Chemotherapy
Année:
2006
Type:
Article
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