Association Analyses of beta3AR Trp64Arg and UCP-2 -866G/A Polymorphisms with Body Mass Index in Korean / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 252-261, 2007.
Article
Dans Coréen
| WPRIM
| ID: wpr-72247
ABSTRACT
BACKGROUND:
Obesity is the most common nutritional disorder in Western society as well as in Korea. Obesity results from a combination of genetic, environmental, and behavioral factors. MATERIALS ANDMETHODS:
In an attempt to investigate the association of obesity with its candidate genes, beta3 adrenergic receptor (beta3AR) and uncoupling protein 2 (UCP2), we analyzed polymorphisms of beta3AR Trp64Arg and UCP2 -866G/A by PCR-RFLP analysis and the obesity-related phenotypes, including body mass index (BMI), fasting glucose concentration, and plasma lipid profiles in 750 subjects.RESULTS:
The Trp64Arg polymorphism in the beta3AR gene was not statistically associated with the BMI. The UCP2 -866G/A polymorphism was significantly higher in obese than in non-obese subjects (P<0.05). However, the UCP2 -866A/A polymorphism was higher in the non-obese subjects.CONCLUSION:
These results suggest that the UCP2 -866G/A polymorphism might be more useful for the prediction of obesity and obesity-associated diseases in Korean patients than the beta3AR Trp64Arg polymorphism.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phénotype
/
Plasma sanguin
/
Indice de masse corporelle
/
Jeûne
/
Récepteurs adrénergiques
/
Glucose
/
Corée
/
Troubles nutritionnels
/
Obésité
Limites du sujet:
Enfant
/
Humains
Pays comme sujet:
Asie
langue:
Coréen
Texte intégral:
Yeungnam University Journal of Medicine
Année:
2007
Type:
Article
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