The Increment of Bone Density in Patients with Spinal Cord Injury after Alendronate Therapy
Journal of the Korean Academy of Rehabilitation Medicine
;
: 187-192, 2005.
Article
Dans Coréen
| WPRIM
| ID: wpr-723366
ABSTRACT
OBJECTIVE:
The aim of this study was to investigate the changes of bone mineral density (BMD) according to the postinjury duration, walking ability, and to assess the effect of oral alendronate therapy on BMD and biochemical markers in patients with spinal cord injury.METHOD:
Forty-eight subjects with spinal cord injury were enrolled. One tablet of Alend(R) (10 mg of sodium alendronate) was administered daily for 6 months. After this, all subjects received placebo for 6 months as the same manner. The baseline quantitative assessments of BMD and biochemical bone markers, serum osteocalcin and C-terminal telopeptide of type I collagen (ICTP), were performed before the administration of drug. The follow up assessments were performed at 6 and 12 months after drug and placebo administration.RESULTS:
The patients treated with oral alendronate showed significantly higher BMD of femur compared with baseline (p <0.05). Also, ICTP showed significant reduction after alendronate therapy. BMD change rate of alendronate therapy was higher in functional ambulation group compared with wheelchair ambulation group. BMD change rate of alendronate therapy was higher than that of placebo administration.CONCLUSION:
Alendronate therapy may be useful in prevention of loss of BMD after spinal cord injury.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sodium
/
Moelle spinale
/
Traumatismes de la moelle épinière
/
Fauteuils roulants
/
Marqueurs biologiques
/
Densité osseuse
/
Ostéocalcine
/
Études de suivi
/
Marche à pied
/
Alendronate
Type d'étude:
Essai clinique contrôlé
/
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Journal of the Korean Academy of Rehabilitation Medicine
Année:
2005
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS