Heptachlor induced nigral dopaminergic neuronal loss and Parkinsonism-like movement deficits in mice
Experimental & Molecular Medicine
;
: e80-2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-72399
ABSTRACT
Epidemiological studies have suggested an association between pesticide exposure and Parkinson's disease. In this study, we examined the neurotoxicity of an organochlorine pesticide, heptachlor, in vitro and in vivo. In cultured SH-SY5Y cells, heptachlor induced mitochondria-mediated apoptosis. When injected into mice intraperitoneally on a subchronic schedule, heptachlor induced selective loss of dopaminergic neurons in the substantia nigra pars compacta. In addition, the heptachlor injection induced gliosis of microglia and astrocytes selectively in the ventral midbrain area. When the general locomotor activities were monitored by open field test, the heptachlor injection did not induce any gross motor dysfunction. However, the compound induced Parkinsonism-like movement deficits when assessed by a gait and a pole test. These results suggest that heptachlor can induce Parkinson's disease-related neurotoxicities in vivo.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pesticides
/
Substantia nigra
/
Cellules cultivées
/
Astrocytes
/
Apoptose
/
Syndromes parkinsoniens
/
Syndromes neurotoxiques
/
Lignée cellulaire tumorale
/
Neurones dopaminergiques
/
Démarche
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Experimental & Molecular Medicine
Année:
2014
Type:
Article
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