The Expression of HOX D3 and Vascular Endothelial Growth Factor-C in Skin Tumors / 대한피부과학회지
Korean Journal of Dermatology
; : 354-361, 2007.
Article
de Ko
| WPRIM
| ID: wpr-72444
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND: The anatomical relation between a malignant tumor and its vascular and lymphatic bed is an important influencing metastasis. Hox D3 is required for these expressions of integrin alpha v beta3 and urokinase plasminogen activator (uPA), which contribute to endothelial cell adhesion, invasion, and migration during angiogenesis. Recent studies in different tumor types have shown that vascular endothelial growth factor-C (VEGF-C), which displays a high specificity for lymphatic endothelium, is involved in tumor-induced lymphagiogenesis and lymphatic metastatic spread. OBJECTIVE: This study was designed to measure the expression of HOX D3 and VEGF-C in different skin cancers. METHODS: The expression of HOX D3 and VEGF-C was examined by immunohistochemical staining of 40 skin cancer tissue samples, including 8 keratoacanthomas, 8 extramammary paget's disease, 8 basal cell carcinomas, 8 squamous cell carcinomas and 8 malignant melanomas. RESULTS: Immunohistochemical analysis of 40 skin cancer tissue samples revealed a high expression of HOX D3 and VEGF-C in the more aggressive and invasive skin tumors, including squamous cell carcinomas and malignant melanomas. On the other hand, low expression was seen in the less-invasive skin tumors, including keratoacanthomas, extramammary paget's disease and basal cell carcinomas. Also the degree of expression of HOX D3 and VEGF-C showed a statistically-significant correlation with each skin tumor (p<0.05). CONCLUSION: These findings provide evidence that the upregulation of HOX D3 and VEGF-C might be involved in the promotion of angiogenesis and lymphagiogenesis in skin tumors and play an important role in metastasis.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Peau
/
Tumeurs cutanées
/
Endothélium lymphatique
/
Carcinome basocellulaire
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Carcinome épidermoïde
/
Activateurs du plasminogène
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Activateur du plasminogène de type urokinase
/
Régulation positive
/
Sensibilité et spécificité
/
Maladie de Paget extramammaire
Type d'étude:
Diagnostic_studies
langue:
Ko
Texte intégral:
Korean Journal of Dermatology
Année:
2007
Type:
Article