Effects of Transplantation of Human Embryonic Stem Cellson Functional Recovery in Spinal Cord Injured Rats
Journal of the Korean Academy of Rehabilitation Medicine
;
: 491-500, 2008.
Article
Dans Anglais
| WPRIM
| ID: wpr-724668
ABSTRACT
OBJECTIVE:
To investigate the functional recovery following the transplantation of human embryonic stem (hES) cells into an injured rat spinal cord.METHOD:
Sprague-Dawley rats were subjected to the spinal cord injury (SCI) using the New York University impactor. The rats were randomly allocated into three groups of 12 rats each, one media-treated and two hES cell-transplanted groups (5x10(3)/5microliter, 2x10(4)/5microliter). The hES cells were transplanted 1 week after a SCI.RESULTS:
The hES cells transplanted into the rats were found to promote the hind limb performance 8 weeks after transplantation. In the electrophysiological study, the transplanted rats showed significantly shortened latencies and increased amplitudes of motor and somatosensory evoked potentials, compared to the media-treated rats. In the spinal cord of the hES cell-treated group, the pathological findings including the glial scar formation and degenerative changes were attenuated and the human Tau protein-positive cells were identified in the vicinity of the necrotic cavity and in the white matter.CONCLUSION:
These results suggest that the transplantation of hES cells might play a role in promoting the functional recovery after a SCI.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Moelle spinale
/
Traumatismes de la moelle épinière
/
État de New York
/
Cicatrice
/
Rat Sprague-Dawley
/
Transplants
/
Potentiels évoqués somatosensoriels
/
Membres
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
/
Humains
Pays comme sujet:
Amérique du Nord
langue:
Anglais
Texte intégral:
Journal of the Korean Academy of Rehabilitation Medicine
Année:
2008
Type:
Article
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