Effect of Pretreatment of (-)-3-PPP on the Haloperidol-Induced Extracellular Dopamine Concentraions in the Nucleus Accumbens of Rats
Journal of the Korean Society of Biological Psychiatry
; : 79-84, 2001.
Article
de Ko
| WPRIM
| ID: wpr-724986
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVES: To investigate the effects of (-)-3-PPP(0.5, 2, and 10mg/kg, s.c.) and haloperidol(0.1, 0.5, and 2mg/kg, s.c.) on the extracellular dopamine concentrations, and the effect of pretreatment with (-)-3-PPP(2mg/kg) on the haloperidol(2mg/kg)-induced extracellular dopamine concentrations in the nucleus accumbens(NAS) of free moving rats. METHODS: Dopamine levels in dialysate were determined with high pressure liquid chromatography(HPLC) with electrochemical detection(ECD). RESULTS: (1) (-)-3-PPP had dual actions depending on the doses : at 2mg/kg, it decreased and at 10mg/kg, increased extracellular dopamine concentrations ; (2) haloperidol at all doses increased dopamine levels with higher dose having a greater icrease ; and (3) pretreatment of (-)-3-PPP reduced the increase in dopamine levels elicited by acute treatment with haloperidol. CONCLUSIONS: These findings suggest that pretreatment of (-)-3-PPP in low dose could accelerate the onset of therapeutic effect of haloperidol by diminishing the haloperidol-induced dopamine release in the limbic system.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Dopamine
/
Halopéridol
/
Système limbique
/
Noyau accumbens
Limites du sujet:
Animals
langue:
Ko
Texte intégral:
Journal of the Korean Society of Biological Psychiatry
Année:
2001
Type:
Article