Influence of gestational age at exposure on the prenatal effects of gamma-radiation
Journal of Veterinary Science
;
: 37-42, 2001.
Article
Dans Anglais
| WPRIM
| ID: wpr-72521
ABSTRACT
The objective of this investigation was to evaluate the influence of gestational age at exposure on the prenatal effects of gamma-radiation. Pregnant ICR mice were exposed to a single dose of 2.0 Gy gamma-radiation at a gestational 2.5 to 15.5 days post-coitus (p.c.). The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality, growth retardation, change in head size and any other morphological abnormalities. The only demonstrable effect of irradiation during the preimplantation period was an increase in prenatal mortality. Resorptions were maximal on post-exposure day 2.5 after conception. The pre-implantation irradiated embryos which survived did not show any major fetal abnormalities. Small head, growth retardation, cleft palate, dilatation of the cerebral ventricle, dilatation of the renal pelvis and abnormalities of the extremities and tail were prominent after exposure during the organogenesis period, especially on day 11.5 of gestation. Our results indicate that the late period of organogenesis in the mouse is a particularly sensitive phase in terms of the development of the brain, skull and extremities.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Effets différés de l'exposition prénatale à des facteurs de risque
/
Malformations radio-induites
/
Os et tissu osseux
/
Gestation animale
/
Âge gestationnel
/
Mort foetale
/
Rayons gamma
/
Souris de lignée ICR
Limites du sujet:
Animaux
/
Grossesse
langue:
Anglais
Texte intégral:
Journal of Veterinary Science
Année:
2001
Type:
Article
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