Dosage Dependent Neurologic Impairment after Cerebral Air Embolism in Rabbit / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 691-697, 1996.
Article
Dans Coréen
| WPRIM
| ID: wpr-72624
ABSTRACT
BACKGROUND:
A long-term objective is to understand the pathogenesis of neurologic injuries associated with cardiac surgery, cardiopulmonary bypass, and circulatory arrest. Our specific aims are to establish a dose of air which results in moderate to severe neurologic defects in normothermic (37degrees C) rabbits.METHODS:
To first establish a dose of air which would cause unequivocal neurologic impairment, anesthetized rabbits received either 0, 50, 100 or 150 microgram l/kg of air into the internal carotid artery(n=5 in each group). One hour later, anesthesia was discontinued and animals were recovered. Animal were neurologically evaluated at 24 hours using a zero(normal) to 97(coma) point scale.RESULTS:
There was a clear relationship between the dose of air injected and the severity of neurologic impairment at 24 hours, p=1.1x10(-7). Rabbits receiving 50 micrograml/kg of air were minimally affected and were difficult to distinguish from controls. In contrast, rabbits receiving 150 micrograml/kg of air were uniformly and unequivocally impaired.CONCLUSION:
we recommend for future cerebral air embolism studies, 150 microgram l/kg as the optimal dose of air which would reliably produce viable subjects for 24 hours with marked unequivocal, neurologic impairment.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Chirurgie thoracique
/
Encéphale
/
Pontage cardiopulmonaire
/
Embolie
/
Embolie gazeuse
/
Anesthésie
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
Korean Journal of Anesthesiology
Année:
1996
Type:
Article
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