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Effects of Thyroxine on Hyperkalemia and Renal Cortical Na(+), K(+) - ATPase Activity Induced by Cyclosporin A
Journal of Korean Medical Science ; : 625-632, 2002.
Article Dans Anglais | WPRIM | ID: wpr-72669
ABSTRACT
Cyclosporin A (CsA)-induced hyperkalemia is caused by alterations in transepithelial K(+) secretion resulting from the inhibition of renal tubular Na(+), K(+) -ATPase activity. Thyroxine enhances renal cortical Na(+), K(+) -ATPase activity. This study investigated the effect of thyroxine on CsA-induced hyperkalemia. Sprague-Dawley rats were treated with either CsA, thyroxine, CsA and thyroxine, or olive-oil vehicle. CsA resulted in an increase in BUN and serum K(+), along with a decrease in creatinine clearance, fractional excretion of potassium, and renal cortical Na(+), K(+) -ATPase activity, as compared with oil vehicle administration. Histochemical study showed reduced Na(+), K(+) -ATPase activity in the proximal tubular epithelial cells of the CsA-treated compared with the oil-treated rats. Histologically, isometric intracytoplasmic vacuolation, disruption of the arrangement and swelling of the mitochondria, and a large number of lysosomes in the tubular epithelium were characteristic of the CsA-treated rats. Co-administration of thyroxine prevented CsA-induced hyperkalemia and reduced creatinine clearance, Na(+), K(+) -ATPase activity, and severity of the histologic changes in the renal tubular cells when compared with the CsA-treated rats. Thyroxine increased the fractional excretion of potassium via the preservation of Na(+), K(+) -ATPase activity in the renal tubular cells. Thus, the beneficial effects of thyroxine may be suited to treatment modalities for CsA-induced hyperkalemia.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Potassium / Thyroxine / Ciclosporine / Rat Sprague-Dawley / Sodium-Potassium-Exchanging ATPase / Hyperkaliémie / Immunosuppresseurs / Cortex rénal / Microsomes Limites du sujet: Animaux langue: Anglais Texte intégral: Journal of Korean Medical Science Année: 2002 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Potassium / Thyroxine / Ciclosporine / Rat Sprague-Dawley / Sodium-Potassium-Exchanging ATPase / Hyperkaliémie / Immunosuppresseurs / Cortex rénal / Microsomes Limites du sujet: Animaux langue: Anglais Texte intégral: Journal of Korean Medical Science Année: 2002 Type: Article