Zerumbone, Sesquiterpene Photochemical from Ginger, Inhibits Angiogenesis
The Korean Journal of Physiology and Pharmacology
;
: 335-340, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-727365
ABSTRACT
Here, we investigated the role of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, on angiogenesis using human umbilical vein endothelial cells (HUVECs). Zerumbone inhibited HUVECs proliferation, migration and tubule formation, as well as angiogenic activity by rat aorta explants. In particular, zerumbone inhibited phosphorylation of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1, which are key regulators of endothelial cell function and angiogenesis. In vivo matrigel plug assay in mice demonstrated significant decrease in vascularization and hemoglobin content in the plugs from zerumbone-treated mice, compared with control mice. Overall, these results suggest that zerumbone inhibits various attributes of angiogenesis, which might contribute to its reported antitumor effects.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Aorte
/
Phosphorylation
/
Zingiber officinale
/
Récepteurs aux facteurs de croissance endothéliale vasculaire
/
Récepteur-2 au facteur croissance endothéliale vasculaire
/
Cellules endothéliales
/
Cellules endothéliales de la veine ombilicale humaine
/
Facteurs de croissance fibroblastique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
The Korean Journal of Physiology and Pharmacology
Année:
2015
Type:
Article
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