Physiological and pharmacological characterization of glutamate and GABA receptors in the retina
The Korean Journal of Physiology and Pharmacology
;
: 461-469, 1999.
Article
Dans Anglais
| WPRIM
| ID: wpr-727848
ABSTRACT
Glutamate and gamma-aminobutyric acid (GABA) are major excitatory and inhibitory neurotransmitters in the vertebrate retina, respectively. Using the whole-cell patch clamp technique and a rapid solution changer, glutamate and GABA receptors have been extensively investigated in carp retina. Glutamate receptors on both horizontal and amacrine cells may be an AMPA preferring subtype, which predominantly consists of flop splice variants. GABAA and GABAC receptors coexist in bipolar cells and they both show significant desensitization. Kinetics analysis demonstrated that activation, deactivation and desensitization of the GABAC receptor-mediated response of these cells are overall slower than those of the GABAA response. Endogenous modulator Zn2+ in the retina was found to differentially modulate the kinetic characteristics of the GABAC and GABAA responses.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Rétine
/
Vertébrés
/
Carpes (poisson)
/
Cinétique
/
Récepteurs au glutamate
/
Récepteurs GABA
/
AMPA
/
Agents neuromédiateurs
/
Acide glutamique
/
Cellules amacrines
langue:
Anglais
Texte intégral:
The Korean Journal of Physiology and Pharmacology
Année:
1999
Type:
Article
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