Gap Junction Contributions to the Goldfish Electroretinogram at the Photopic Illumination Level
The Korean Journal of Physiology and Pharmacology
;
: 219-224, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-728097
ABSTRACT
Understanding how the b-wave of the electroretinogram (ERG) is generated by full-field light stimulation is still a challenge in visual neuroscience. To understand more about the origin of the b-wave, we studied the contributions of gap junctions to the ERG b-wave. Many types of retinal neurons are connected to similar and different neighboring neurons through gap junctions. The photopic (cone-dominated) ERG, stimulated by a small light beam, was recorded from goldfish (Carassius auratus) using a corneal electrode. Data were obtained before and after intravitreal injection of agents into the eye under a photopic illumination level. Several agents were used to affect gap junctions, such as dopamine D1 and D2 receptor agonists and antagonists, a nitric oxide (NO) donor, a nitric oxide synthase (NOS) inhibitor, the gap junction blocker meclofenamic acid (MFA), and mixtures of these agents. The ERG b-waves, which were enhanced by MFA, sodium nitroprusside (SNP), SKF 38393, and sulpiride, remained following application of a further injection of a mixture with MFA. The ERG b-waves decreased following NG-nitro-L-arginine methyl ester (L-NAME), SCH 23390, and quinpirole administration but were enhanced by further injection of a mixture with MFA. These results indicate that gap junction activity influences b-waves of the ERG related to NO and dopamine actions.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sulpiride
/
Donneurs de tissus
/
Benzazépines
/
Neurosciences
/
Éclairage
/
Poisson rouge
/
Nitroprussiate
/
Dopamine
/
1-Phényl-2,3,4,5-tétrahydro-1H-3-benzazépine-7,8-diol
/
Acide méclofénamique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
The Korean Journal of Physiology and Pharmacology
Année:
2012
Type:
Article
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