Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats
The Korean Journal of Physiology and Pharmacology
;
: 9-13, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-728178
ABSTRACT
The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Perfusion
/
Perméabilité
/
Phosphatidylcholines
/
Dodécyl-sulfate de sodium
/
Naphtoquinones
/
Acide désoxycholique
/
Absorption
/
Absorption intestinale
/
Gros intestin
/
Micelles
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
The Korean Journal of Physiology and Pharmacology
Année:
2013
Type:
Article
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