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Scopoletin from Cirsium setidens Increases Melanin Synthesis via CREB Phosphorylation in B16F10 Cells
The Korean Journal of Physiology and Pharmacology ; : 307-311, 2014.
Article Dans Anglais | WPRIM | ID: wpr-728464
ABSTRACT
In this study, we isolated scopoletin from Cirsium setidens Nakai (Compositae) and tested its effects on melanogenesis. Scopoletin was not toxic to cells at concentrations less than 50 microM and increased melanin synthesis in a dose-dependent manner. As melanin synthesis increased, scopoletin stimulated the total tyrosinase activity, the rate-limiting enzyme of melanogenesis. In a cell-free system, however, scopoletin did not increase tyrosinase activity, indicating that scopoletin is not a direct activator of tyrosinase. Furthermore, Western blot analysis showed that scopoletin stimulated the production of microphthalmia-associated transcription factor (MITF) and tyrosinase expression via cAMP response element-binding protein (CREB) phosphorylation in a dose-dependent manner. Based on these results, preclinical and clinical studies are needed to assess the use of scopoletin for the treatment of vitiligo.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Phosphorylation / Scopolétine / Vitiligo / Système acellulaire / Technique de Western / Monophenol monooxygenase / Protéine de liaison à l'élément de réponse à l'AMP cyclique / Cirsium / Facteur de transcription associé à la microphtalmie / Mélanines langue: Anglais Texte intégral: The Korean Journal of Physiology and Pharmacology Année: 2014 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Phosphorylation / Scopolétine / Vitiligo / Système acellulaire / Technique de Western / Monophenol monooxygenase / Protéine de liaison à l'élément de réponse à l'AMP cyclique / Cirsium / Facteur de transcription associé à la microphtalmie / Mélanines langue: Anglais Texte intégral: The Korean Journal of Physiology and Pharmacology Année: 2014 Type: Article