Chronic Non-Social Stress Affects Depressive Behaviors But Not Anxiety in Mice
The Korean Journal of Physiology and Pharmacology
;
: 263-268, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-728469
ABSTRACT
The etiology of most psychiatric disorders is still incompletely understood. However, growing evidence suggests that stress is a potent environmental risk factor for depression and anxiety. In rodents, various stress paradigms have been developed, but psychosocial stress paradigms have received more attention than non-social stress paradigms because psychosocial stress is more prevalent in humans. Interestingly, some recent studies suggest that chronic psychosocial stress and social isolation affects mainly anxiety-related behaviors in mice. However, it is unclear whether chronic non-social stress induces both depression- and anxiety-related phenotypes or induces one specific phenotype in mice. In the present study, we examined the behavioral consequences of three chronic non-social stress paradigms chronic predictable (restraint) stress (CPS), chronic unpredictable stress (CUS), and repeated corticosterone-HBC complex injection (RCI). Each of the three paradigms induced mild to severe depression/despair-like behaviors in mice and resulted in increased immobility in a tail suspension test. However, anxiety-related phenotypes, thigmotaxis and explorative behaviors, were not changed by the three paradigms. These results suggest that depression- and anxiety-related phenotypes can be dissociated in mouse stress models and that social and non-social stressors might affect brain circuits and behaviors differently.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anxiété
/
Phénotype
/
Rodentia
/
Isolement social
/
Encéphale
/
Facteurs de risque
/
Suspension des membres postérieurs
/
Dépression
Type d'étude:
Etude d'étiologie
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
The Korean Journal of Physiology and Pharmacology
Année:
2014
Type:
Article
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