Examples and outlook of family-based cohort study / 한국역학회지
Korean Journal of Epidemiology
;
: 49-59, 2008.
Article
Dans Coréen
| WPRIM
| ID: wpr-729063
ABSTRACT
Family-based designs are commonly used in genetic association studies to identify and to locate genes that underlie complex diseases. In this paper, we review two examples of genome-wide association studies using family-based cohort studies, including the Framingham Heart Study and International Multi-Center ADHD Genetics Project. We also review statistical methods of family-based designs, including the transmission disequilibrium test (TDT), linkage analysis, and imprinting effect analysis. In addition, we evaluate the strengths and limitations of the family-based cohort design. Despite the costs and difficulties in carrying out this type of study, a family-based cohort study can play avery important role in genome wide studies. First, the design will be free from biases due to population heterogeneity or stratification. Moreover, family-based designs provide the opportunity to conduct joint tests of linkage and association. Finally, family-based designs also allow access to epigenetic phenomena like imprinting. The family-based cohort design should be given careful consideration in planning new studies for genome-wide strategies.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Caractéristiques de la population
/
Biais (épidémiologie)
/
Études de cohortes
/
Génome
/
Levage
/
Étude d'association pangénomique
/
Études d'associations génétiques
/
Épigénomique
/
Coeur
/
Articulations
Type d'étude:
Essai clinique contrôlé
/
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
langue:
Coréen
Texte intégral:
Korean Journal of Epidemiology
Année:
2008
Type:
Article
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