Effects of Maxing-Shigan decoction on inflammatory factors and immune function of children with mycoplasma pneumonia / 国际中医中药杂志

ABSTRACT

Objective To investigate the effect of Maxing-Shigan decoction on inflammatory factors and immune function of mycoplasma pneumonia (MPP). Methods According to the random table method, 123 children with MPP who met the inclusion criteria were divided into control group (61 cases) and treatment group (62 cases). The control group was treated with azithromycin, while the treatment group was treated with Maxing-Shigan decoction on the basis of the control group. The treatment course was two weeks in two groups. The level of IL-2, IL-4, IL-6, TNF-α, CRP and CD3+, CD4+, CD8+ and CD4+/CD8+ was detected by ELISA. The recovery time of body temperature, the fading time of coughing, the fading time of crackles and rale and the time of hospitalization was observed, TCM symptoms and signs was also scored, and the clinical efficacy was evaluated. Results The total effective rate was 90.3％ (56/62) in the treatment group and 73.8％ (45/61) in the control group. There was significant difference between the two groups (χ2=5.736, P=0.017). The recovery time of body temperature, the fading time of coughing, the fading time of crackles and rale and the time of hospitalization in the treatment group was significantly lower than those in the control group (t=-6.969, -5.700,-8.226, -7.034, P<0.01). Compared with the control group after treatment, the serum level of IL-2 significantly increased, IL-4, IL-6, TNF-α and CRP significantly decreased in the treatment group (t=12.729, -6.373, -6.416,-14.482, -20.071, P<0.01), while the serum level of CD3+, CD4+, CD4+/CD8+ significantly increased and CD8+significantly decreased in the treatment group (t=2.314, 2.556, -3.866, 11.226, P<0.05). Conclusions The Maxing-Shigan decoction treats MPP by improving inflammatory factors and immune function, which not only improve the clinical symptoms, but also has high safety. It is worth promoting the application in clinic.