The clinical effect of Qinggan-Jiedu decoction adjuvant microwave coagulation therapy on the patients of liver cancer / 国际中医中药杂志

ABSTRACT

Objective To the curative effect of treating liver cancer with the Qinggan-Jiedu decoction adjuvant microwave coagulation therapy. Methods A total of 63 liver cancer patients were randomly divided into the treatment group (n=35) and the control group (n=28). On the basis of this, the control group was treated only with microwave coagulation therapy, while the treatment group was treated with Qinggan-Jiedu decoction for 14 days on the basis of the control group. Before and after treatment, Karnofsky Performance status score (KPS) was used to evaluate the quality of life, and the changes of symptoms and signs such as fever, anorexia, abdominal distention and liver pain were observed, and the changes of tumor focus were observed by B-mode ultrasonography. Blood routine, ALT, AST, TBil and tumor markers were detected by ELISA. Results The total effective rate was 71.4％ (25/35) in the treatment group and 46.4％ (13/28) in the control group. There was significant difference between the two groups (χ2=4.062, P=0.044). After treatment, the KPS scores of the two groups (86. 6 ± 9. 6 vs. 80. 4 ± 7. 9, t=2.751) were higher than those of the control group (P=0.008). The scores of ALT (59.4 ± 27.6 U/L vs. 85.1 ± 30.8 U/L, t=3.488) and AST (53.9 ± 24.4 U/L vs. 82.3 ± 27.6 U/L, t=4.331) in the treatment group were lower than those in the control group (P<0.01). After treatment, the liver focus disappeared in both groups. Conclusions Qinggan-Jiedu decoction can reduce the degree of liver injury and improve the quality of life in liver cancer patients after microwave coagulation therapy.