Research of immunoglobulin-resistant Kawasaki disease / 中华实用儿科临床杂志

ABSTRACT

High-dose intravenous gamma globulin (2 g/kg) combined with oral aspirin is currently considered as standard strategy for Kawasaki disease (KD) in initial treatment.However,there are still 15％-25％ of KD patients with no response to the treatment,thus leading to persistent fever,or even further damage of the coronary arteries.International literature have also mentioned other methods of treatment,such as corticosteroids,TNF-α blockade,lyclosporin,IL-1 receptor blockade,methotrexate,anti-CD20 rituximab,plasma exchange.But fixed standard for non-reactive gamma globulin require for further treatment.