Hydrogen suppresses the inflammatory response of rat abdominal aorta after percutaneous transluminal angiography / 中华普通外科杂志

ABSTRACT

Objective To investigate the effect of hydrogen on the inflammatory response of abdominal aorta after atherosclerotic percutaneous transluminal angiography (PTA) in rats.Methods 40 established model of atherosclerosis Wistar rats were divided into 2 groups,one week before PTA to be injected intraperitoneally with hydrogen-saturated saline (experimental group) and normal saline (control group).The vascular structures were observed by HE.Interleukin-1 β (IL-1β) and tumor necrosis factor-α (TNF-α) were detected by ELISA.Plasma interleukin-6 (IL-6) was measured.Results The intima/ media ratio of aorta in experimental group and control group were 0.111 ± 0.015 and 0.173 ± 0.028 respectively,t =4.728,P ＜ 0.01;the IL-1β concentrations were (83 ± 27) ng/L and (163 ± 48) ng/L,respectively,t =5.081,P ＜ 0.01;the TNF-α concentrations were (107 ± 39)ng/L and (353 ± 54)ng/L,respectively,t =9.832,P ＜ 0.01.The degree of hyperplasia and expression of inflammatory factor were lower in experimental group than in the control group.Also,the plasma IL-6 was lower.Conclusion Hydrogen can inhibit the expression of inflammatory factors such as IL-1β3,TNF-α,IL-6 after PTA of abdominal aorta in rats,thereby inhibiting intimal hyperplasia.