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Effect of baseline CD4+ T cell count on drop-out of antiretroviral therapy in HIV infected persons in Guangxi Zhuang Autonomous Region, 2008-2015 / 中华流行病学杂志
Chinese Journal of Epidemiology ; (12): 1216-1221, 2018.
Article de Zh | WPRIM | ID: wpr-736658
Bibliothèque responsable: WPRO
ABSTRACT
Objective To investigate the effect of baseline CD4+T cell count (CD4) on drop-out of antiretroviral therapy (ART) in HIV infected persons.Methods Retrospective cohort was conducted in this study.HIV infected persons aged≥ 18 years and receiving free ART for the first time in Guangxi Zhuang Autonomous Region (Guangxi) from 2008 to 2015 were selected from the antiretroviral treatment database of National Comprehensive HIV/AIDS Information System,with follow-up conducted till May 30,2016.Cause-specific Cox proportional hazard models were used to evaluate effect of different CD4 on the drop-out of ART in the HIV infected persons.Results A total of 58 502 eligible study participants were included in this retrospective cohort study.The average drop-out ratio was 4.8/100 person-years.After controlling the following baseline covariates:age,sex,marital status,route of HIV infection,WHO clinical stage before ART,initial/current ART regiment,ART regiment adjustment,and year of initiating ART for potential confounding,the adjusted HR of drop-out for HIV infected persons with 200-cells/μl,351-cells/μl and ≥500 cells/μl were 1.110 (95%CI:1.053-1.171,P<0.001),1.391 (95%CI:1.278-1.514,P<0.001) and 1.695 (95%CI:1.497-1.918,P< 0.001),respectively,in risk for drop-out compared with those with baseline CD4 <200 cells/μ 1.Among the HIV infected persons,56.0% (1 601/2 861) of drug withdrawal was due to poor compliance with medication.Conclusions With the increase of baseline CD4 when initiating ART,the risk for the drop-out in HIV infected persons increased significantly.To further reduce the drop-out of ART,it is important to take CD4 into account in initiating ART and to strengthen the health education on treatment compliancy and training for healthcare providers.
Mots clés
Texte intégral: 1 Indice: WPRIM Type d'étude: Observational_studies langue: Zh Texte intégral: Chinese Journal of Epidemiology Année: 2018 Type: Article
Texte intégral: 1 Indice: WPRIM Type d'étude: Observational_studies langue: Zh Texte intégral: Chinese Journal of Epidemiology Année: 2018 Type: Article