Effect of serum hyaluronic acid on the liver cryopreservation-reperfusion injury in rats / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 77-79, 2001.
Article
Dans Chinois
| WPRIM
| ID: wpr-736807
ABSTRACT
Objective:
To investigate the relation between ser um hyaluronic acid (HA) concentration and cryopreservation-reperfusion injury.Methods:
The animals were randomly assigned to 3 groups (1 ) group A the control; (2) group B liver allografts were stored in lactated R inger's solution (0℃) for 2 h before implantation; (3) group Cliver allografts were stored in lactated Ringer's solution (0℃) for 4 h before implantation. Th e serum sample and liver specimen were taken up at 2 h and 4 h after transplanta tion to detect the concentration of HA, AST and LDH, and to get pathologic obser vation.Results:
Serum HA increased earlier and decreased more s hortly than AST and LDH after transplantation in group A. Serum HA increased sig nificantly in group B and C, much higher than that in group A(P<0.01). The i njury of vascular endothelium and the disorder of hepatic sinuses and hepatic lo b ules were observed in group B and C. In the specimen of 4 h in group C, evident infiltration of inflammatory cell was present.Conclusion:
Cryopreservation leads to injury of endothelial cell and reperfusion aggravat es this injury. The serum HA concentration indicates the degree of cold ischemia -reperfusion injury.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Academic Journal of Second Military Medical University
Année:
2001
Type:
Article
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