Elevated Levels of Serum Pentosidine Are Associated with Dropped Head Syndrome in Older Women
Asian Spine Journal
;
: 155-162, 2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-739300
ABSTRACT
STUDY DESIGN:
A retrospective observational study was performed.PURPOSE:
We investigated the prevalence of sarcopenia in dropped head syndrome (DHS), and the relationship between biochemical markers, including major advanced glycation end products (AGEs), pentosidine, and DHS in older women. OVERVIEW OF LITERATURE AGEs have been implicated in the pathogenesis of sarcopenia.METHODS:
We studied 13 elderly women with idiopathic DHS (mean age, 77.2 years) and 20 healthy volunteers (mean age, 74.8 years). We used a bioelectrical impedance analyzer to analyze body composition, including appendicular skeletal muscle mass index (SMI; appendicular lean mass [kg]/[height (m)]2). Cervical sagittal plane alignment, including C2–C7 sagittal vertical axis (C2–C7SVA), C2–C7 angle, and C2 slope (C2S), was measured. Biochemical markers, such as serum and urinary pentosidine, serum homocysteine, 1, 25-dihydroxyvitamin D, and 25-hydroxyvitamin D, were measured. The level of each variable was compared between DHS and controls. The relationship between biochemical markers and DHS was examined.RESULTS:
Sarcopenia (SMI < 5.75) was observed at a high prevalence in participants with DHS (77% compared to 22% of healthy controls). Height, weight, femoral bone mineral density, appendicular lean mass, total lean mass, and SMI all had significantly lower values in the DHS group. Serum and urinary pentosidine, and serum homocysteine were significantly higher in the DHS group compared to controls. Analysis of cervical alignment revealed a significant positive correlation of serum pentosidine with C2–C7SVA and C2S.CONCLUSIONS:
Sarcopenia was involved in DHS, and high serum pentosidine levels are associated with severity of DHS in older women.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Composition corporelle
/
Marqueurs biologiques
/
Densité osseuse
/
Prévalence
/
Études rétrospectives
/
Impédance électrique
/
Muscles squelettiques
/
Sarcopénie
/
Volontaires sains
/
Étude d'observation
Type d'étude:
Étude observationnelle
/
Étude de prévalence
/
Facteurs de risque
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Asian Spine Journal
Année:
2019
Type:
Article
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