HisCoM-GGI: Software for Hierarchical Structural Component Analysis of Gene-Gene Interactions
Genomics & Informatics
;
: e38-2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-739675
ABSTRACT
Gene-gene interaction (GGI) analysis is known to play an important role in explaining missing heritability. Many previous studies have already proposed software to analyze GGI, but most methods focus on a binary phenotype in a case-control design. In this study, we developed “Hierarchical structural CoMponent analysis of Gene-Gene Interactions” (HisCoM-GGI) software for GGI analysis with a continuous phenotype. The HisCoM-GGI method considers hierarchical structural relationships between genes and single nucleotide polymorphisms (SNPs), enabling both gene-level and SNP-level interaction analysis in a single model. Furthermore, this software accepts various types of genomic data and supports data management and multithreading to improve the efficiency of genome-wide association study data analysis. We expect that HisCoM-GGI software will provide advanced accessibility to researchers in genetic interaction studies and a more effective way to understand biological mechanisms of complex diseases.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phénotype
/
Études cas-témoins
/
Statistiques comme sujet
/
Polymorphisme de nucléotide simple
/
Étude d'association pangénomique
/
Méthodes
Type d'étude:
Étude observationnelle
/
Facteurs de risque
langue:
Anglais
Texte intégral:
Genomics & Informatics
Année:
2018
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS