Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer
Genomics & Informatics
; : e35-2018.
Article
Dans En
| WPRIM
| ID: wpr-739678
Responsable en Bibliothèque :
WPRO
ABSTRACT
Biliary tract cancer (BTC) is a rare cancer and is associated with a poor prognosis. To understand the genetic characteristics of BTC, we analyzed whole-exome sequencing data and identified somatic mutations in patients with BTC. Tumors and matched blood or normal samples were obtained from seven patients with cholangiocarcinoma who underwent surgical resection. We discovered inactivating mutations of tumor suppressor genes, including APC, TP53, and ARID1A, in three patients. Activating mutations of KRAS and NRAS were also identified. Our analyses identified somatic mutations in Korean patients with BTC
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pronostic
/
Voies biliaires
/
Tumeurs des voies biliaires
/
Gènes suppresseurs de tumeur
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Cholangiocarcinome
/
Exome
Type d'étude:
Prognostic_studies
Limites du sujet:
Humans
langue:
En
Texte intégral:
Genomics & Informatics
Année:
2018
Type:
Article