Preliminary assessment of correlation between T-lymphocyte responses and control of porcine reproductive and respiratory syndrome virus (PRRSV) in piglets born after in-utero infection of a type 2 PRRSV / 대한수의학회지
Korean Journal of Veterinary Research
;
: 9-16, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-741493
ABSTRACT
A preliminary study into the protective mechanisms of adaptive immunity against porcine reproductive and respiratory syndrome virus (PRRSV) in piglets (n = 9) born to a gilt challenged intranasally with a type-2 PRRSV. Immune parameters (neutralizing antibodies, CD3⁺CD4⁺, CD3⁺CD8⁺, CD3⁺CD4⁺CD8⁺ T-lymphocytes, and PRRSV-specific interferon (IFN)-γ secreting T-lymphocytes) were compared with infection parameters (macro- and microscopic lung lesion, and PRRSV-infected porcine alveolar macrophages (CD172α⁺PRRSV-N⁺ PAM) as well as with plasma and lymphoid tissue viral loads. Percentages of three T-lymphocyte phenotypes in 14-days post-birth (dpb) peripheral blood mononuclear cell (PBMC) had significant negative correlations with percentages of CD172α⁺PRRSV-N⁺ PAM (p 0.1) with infection parameters. The results indicate that T-lymphocytes contribute to controlling PRRSV replication in young piglets born after in-utero infection.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phénotype
/
Plasma sanguin
/
Lymphocytes T
/
Interférons
/
Macrophages alvéolaires
/
Virus du syndrome respiratoire et reproducteur porcin
/
Syndrome dysgénésique et respiratoire porcin
/
Charge virale
/
Anticorps neutralisants
/
Immunité acquise
langue:
Anglais
Texte intégral:
Korean Journal of Veterinary Research
Année:
2018
Type:
Article
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