Garcinexanthone G, a Selective Butyrylcholinesterase Inhibitor from the Stem Bark of Garcinia atroviridis
Natural Product Sciences
;
: 88-92, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-741612
ABSTRACT
The present study was undertaken to investigate the isolated compounds from the stem bark of Garcinia atroviridis as potential cholinesterase inhibitors and the ligand-enzyme interactions of selected bioactive compounds in silico. The in vitro cholinesterase results showed that quercetin (3) was the most active AChE inhibitor (12.65 ± 1.57 µg/ml) while garcinexanthone G (6) was the most active BChE inhibitor (18.86 ± 2.41 µg/ml). It is noteworthy to note that compound 6 was a selective inhibitor with the selectivity index of 11.82. Molecular insight from docking interaction further substantiate that orientation of compound 6 in the catalytic site which enhanced its binding affinity as compared to other xanthones. The nature of protein-ligand interactions of compound 6 is mainly hydrogen bonding, and the hydroxyl group of compound 6 at C-10 is vital in BChE inhibition activity. Therefore, compound 6 is a notable lead for further drug design and development of BChE selective inhibitor.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Quercétine
/
Techniques in vitro
/
Simulation numérique
/
Butyrylcholine esterase
/
Conception de médicament
/
Anticholinestérasiques
/
Cholinesterases
/
Domaine catalytique
/
Garcinia
/
Xanthones
langue:
Anglais
Texte intégral:
Natural Product Sciences
Année:
2018
Type:
Article
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