Your browser doesn't support javascript.
loading
Isolation of Flavonoid Glycosides with Cholinesterase Inhibition Activity and Quantification from Stachys japonica
Natural Product Sciences ; : 259-265, 2018.
Article Dans Anglais | WPRIM | ID: wpr-741632
ABSTRACT
The three flavone glycosides, 4′-O-methylisoscutellarein 7-O-(6‴-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (1), isoscutellarein 7-O-(6‴-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (3), and isoscutellarein 7-O-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (4) in addition to a flavonol glycoside, kaempferol 3-O-β-D-glucopyranoside (astragalin, 2), were isolated from Stachys japonica (Lamiaceae). In cholinesterase inhibition assay, compound 1 significantly inhibited aceylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities (IC₅₀s, 39.94 µg/ml for AChE and 86.98 µg/ml for BChE). The content of isolated compounds were evaluated in this plant extract by HPLC analysis. Our experimental results suggest that the flavonoid glycosides of S. japonica could prevent the memory impairment of Alzheimer's disease.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Plantes / Butyrylcholine esterase / Cholinesterases / Chromatographie en phase liquide à haute performance / Lamiaceae / Stachys / Maladie d'Alzheimer / Hétérosides / Mémoire langue: Anglais Texte intégral: Natural Product Sciences Année: 2018 Type: Article

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Plantes / Butyrylcholine esterase / Cholinesterases / Chromatographie en phase liquide à haute performance / Lamiaceae / Stachys / Maladie d'Alzheimer / Hétérosides / Mémoire langue: Anglais Texte intégral: Natural Product Sciences Année: 2018 Type: Article